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. Author manuscript; available in PMC: 2020 Mar 5.
Published in final edited form as: ChemMedChem. 2019 Feb 5;14(5):545–560. doi: 10.1002/cmdc.201800725

Scheme 3.

Scheme 3.

Reagents and conditions, a) 16a, 16b or 16c, i-PrOH, 18 h, 80 °C, 65–71%; b) TFA, dry CH2Cl2, 2 h, from 0 °C to 25 °C; c) Acids 4a–d, EDCI·HCl, HOBt·H2O, DIPEA, dry CH2Cl2, 15 h, 25 °C, 55–71% (2 steps).