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. Author manuscript; available in PMC: 2020 Mar 5.
Published in final edited form as: ChemMedChem. 2019 Feb 5;14(5):545–560. doi: 10.1002/cmdc.201800725

Table 1.

Structure and activity on BACE1 and BACE2 enzymes for title inhibitors 2a–j.

Inhibitor Ki (nM)a BACE1 Ki (nM)b BACE2
graphic file with name nihms-1029330-t0014.jpg 45.6 14.6
graphic file with name nihms-1029330-t0015.jpg 1812 80.5
graphic file with name nihms-1029330-t0016.jpg 731 182.8
graphic file with name nihms-1029330-t0017.jpg 5244 0.031
graphic file with name nihms-1029330-t0018.jpg 563.5 0.038
graphic file with name nihms-1029330-t0019.jpg 3022 1366
graphic file with name nihms-1029330-t0020.jpg 6.6 27.9
graphic file with name nihms-1029330-t0021.jpg 176.2 96.9
graphic file with name nihms-1029330-t0022.jpg 33.1 51.1
graphic file with name nihms-1029330-t0023.jpg 34.2 25.3
a

Ki values for BACE1 enzyme have been determined as described in ref. 36

b

Ki values for BACE2 enzyme have been determined as described in ref. 36.