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. Author manuscript; available in PMC: 2020 Mar 5.
Published in final edited form as: ChemMedChem. 2019 Feb 5;14(5):545–560. doi: 10.1002/cmdc.201800725

Table 2.

Structure and activity on BACE1 and BACE2 enzymes for title inhibitors 3a–h.

Inhibitor Ki (nM)a BACE1 Ki (nM)b BACE2
graphic file with name nihms-1029330-t0024.jpg 205.3 730.8
graphic file with name nihms-1029330-t0025.jpg 4852 479
graphic file with name nihms-1029330-t0026.jpg 51331 950
graphic file with name nihms-1029330-t0027.jpg 16229 480
graphic file with name nihms-1029330-t0028.jpg 38633 243
graphic file with name nihms-1029330-t0029.jpg 8805 141
graphic file with name nihms-1029330-t0030.jpg 42485 2552
graphic file with name nihms-1029330-t0031.jpg 18130 905
a

Ki values for BACE1 enzyme have been determined as described in ref. 36

b

Ki values for BACE2 enzyme have been determined as described in ref. 36.