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. Author manuscript; available in PMC: 2020 Mar 5.
Published in final edited form as: ChemMedChem. 2019 Feb 5;14(5):545–560. doi: 10.1002/cmdc.201800725

Table 3.

Structure and activity on BACE1 and BACE2 enzymes for title inhibitors 3i–o.

Inhibitor Ki (nM)a BACE1 Ki (nM)b BACE2
graphic file with name nihms-1029330-t0032.jpg 2085 39.45
graphic file with name nihms-1029330-t0033.jpg 837 14.02
graphic file with name nihms-1029330-t0034.jpg 1347 35.71
graphic file with name nihms-1029330-t0035.jpg 815.1 1.6
graphic file with name nihms-1029330-t0036.jpg 68.8 7332
graphic file with name nihms-1029330-t0037.jpg 25.36 1921
graphic file with name nihms-1029330-t0038.jpg 767 801
a

Ki values for BACE1 enzyme have been determined as described in ref. 36

b

Ki values for BACE2 enzyme have been determined as described in ref. 36.