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. 2019 Jul 11;10:1589. doi: 10.3389/fimmu.2019.01589

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Copyright © 2019 Demars, Lison, Machelart, Van Vyve, Potemberg, Vanderwinden, De Bolle, Letesson and Muraille.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CCR7 deficiency reduced the frequency of infected dendritic cells in popliteal draining lymph nodes. Wild-type and CCR7^−/− C57BL/6 mice were infected intradermally with a dose of 10⁷ CFU of eFluor670⁺ labeled B. melitensis and sacrificed at 24 h post infection. The footpad lesion and the popliteal draining lymph nodes were harvested and the cells were isolated and then analyzed by flow cytometry for the expression of eFluor670, MHCII, and CD11c as indicated. The data represent the frequency of eFluor670⁺ cells in cells from footpad lesions (A) and popliteal draining lymph nodes (B) and the phenotype of eFluor670⁺ cells in these tissues (C). Percentage indicates the percentage of cells in each quadrant out of the total cells (A,B) or of the eFluor670⁺ cells (C). LN, lymph node. These results are representative of three independent experiments.