Table 2.

AUC of biomarkers to predict AKI after cardiac surgery

	AUC (95% CI)	Cut-off (Sensitivity, Specificity)	p value
Urine Klotho (ng/umol)
The first postoperative	0.86*** (0.78, 0.94)	0.86 (93.9, 75.9%)	< 0.001
2 h admission to the ICU	0.85 (0.76, 0.94)	0.82 (87.5, 77.6%)	< 0.001
4 h admission to the ICU	0.78*** (0.76, 0.94)	0.70 (90.6, 62.1%)	< 0.001
Urine NGAL (ng/umol)
The first postoperative	0.59 (0.46, 0.71)	4.39 (72.7, 56.6%)	0.177
2 h admission to the ICU	0.78 (0.68, 0.88)	4.49 (87.9, 71.7%)	< 0.001
4 h admission to the ICU	0.57 (0.44, 0.70)	4.64 (57.6, 64.2%)	0.285

AUC Area under the ROC, NGAL Neutrophil gelatinase-associated lipocalin

***P < 0.001 compared with the AUCs of urine NGAL at indicated time points