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. 2019 Jul 18;11:104. doi: 10.1186/s13148-019-0702-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — TET1 oxidation of 5mC through to unmodified cytosine. After the deposition of 5-methylcytosine by the DNMT enzymes it can be oxidised by the TETs to 5-hydroxymethylcytosine, 5-formylcytosine, and then 5-carboxylcytosine, before base excision repair resulting in unmodified cytosine. These iterative oxidation steps can be inhibited by the TCA cycle metabolites succinate and fumarate