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. 2019 Jul 17;14:82. doi: 10.1186/s13000-019-0859-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Morphology and immunophenotype of case 9, which progressed to systemic T-cell lymphoma. a Skin biopsy shows a diffuse, atypical lymphocyte infiltrate, with a marked epidermis and subcutaneous distribution (hematoxylin and eosin stain [H&E], 40×). b Skin biopsy shows medium- to large-sized lymphocytes, with enlarged, oval and pleomorphic nuclei (H&E, 200×). c Strong staining of CD4+ cells (IHC, 200×). d GranB Positive cells (IHC 100×). e Ki67 expression is high in 70% of tumor cells (IHC 100×). f In situ hybridization shows that neoplastic cells are positive for EBV-encoded RNA (100×)