Table 1.
Clinical and biochemical characteristics of surviving and non-surviving MMCAI patients
| Survivors (n = 34) | Non-survivors (n = 34) | P- value | |
|---|---|---|---|
| Age (years) - median (p 25–75) | 59 (47–68) | 63 (53–70) | 0.36 |
| Diabetes mellitus - n (%) | 4 (11.8) | 9 (26.5) | 0.22 |
| Gender female - n (%) | 14 (41.2) | 13 (38.2) | 0.99 |
| Arterial hypertension - n (%) | 19 (55.9) | 16 (47.1) | 0.63 |
| Chronic renal failure - n (%) | 2 (5.9) | 2 (5.9) | 0.99 |
| COPD - n (%) | 1 (2.9) | 1 (2.9) | 0.99 |
| Heart failure - n (%) | 1 (2.9) | 1 (2.9) | 0.99 |
| APACHE-II score - mean ± SD | 20.38 ± 6.89 | 22.85 ± 5.93 | 0.12 |
| GCS score - median (p 25–75) | 7 (6–8) | 6 (3–7) | 0.01 |
| Temperature (°C) - median (p 25–75) | 36.4 (36.0–37.0) | 36.9 (36.0–37.3) | 0.15 |
| Creatinine (mg/dl) - median (p 25–75) | 0.80 (0.60–1.13) | 1.00 (0.70–1.25) | 0.19 |
| Sodium (mEq/L)- median (p 25–75) | 139 (136–145) | 140 (139–145) | 0.38 |
| Bilirubin (mg/dl) - median (p 25–75) | 0.60 (0.40–0.83) | 0.60 (0.33–1.10) | 0.95 |
| Glycemia (g/dL) - median (p 25–75) | 127 (100–170) | 136 (118–162) | 0.40 |
| Lactic acid (mmol/L)-median (p 25–75) | 1.20 (0.90–1.70) | 1.55 (1.00–2.70) | 0.05 |
| PaO2 (mmHg) - median (p 25–75) | 156 (105–293) | 115 (94–267) | 0.26 |
| PaO2/FI02 ratio - mean ± SD | 298 ± 116 | 262 ± 96 | 0.17 |
| INR - median (p 25–75) | 1.06 (1.00–1.20) | 1.20 (1.01–1.31) | 0.07 |
| Fibrinogen (mg/dl) - median (p 25–75) | 443 (416–489) | 419 (337–631) | 0.90 |
| aPTT (seconds) - median (p 25–75) | 28 (25–30) | 27 (26–32) | 0.91 |
| Leukocytes-median*103/mm3 (p 25–75) | 12.4 (9.6–16.9) | 13.9 (9.7–20.1) | 0.32 |
| Hemoglobin (g/dL) - mean ± SD | 12.60 ± 1.73 | 12.82 ± 1.96 | 0.67 |
| Platelets - mean ± SD | 225242 ± 84667 | 179382 ± 61975 | 0.01 |
| Haemorrhagic transformation - n (%) | 7 (20.6) | 6 (17.6) | 0.99 |
| Volumen infarction (ml) - mean ± SD | 162 ± 82 | 182 ± 110 | 0.61 |
| Midline shift (mm) - mean ± SD | 7.47 ± 6.14 | 9.09 ± 6.60 | 0.44 |
| Thrombolysis - n (%) | 11 (32.4) | 10 (29.4) | 0.99 |
| Decompressive craniectomy – n (%) | 9 (26.5) | 7 (20.6) | 0.78 |
| MMP-9 (ng/mL) - median (p 25–75) | 839 (719–1192) | 708 (396–949) | 0.03 |
| TIMP-1 (ng/mL) - median (p 25–75) | 206 (173–262) | 375 (248–468) | < 0.001 |
P 25–75 Percentile 25th–75th, SD Standard deviation, COPD Chronic obstructive pulmonary disease, APACHE II Acute Physiology and Chronic Health Evaluation, GCS Glasgow Coma Scale, PaO2 Pressure of arterial oxygen/fraction inspired oxygen, FIO2 Pressure of arterial oxygen/fraction inspired oxygen, INR International normalized ratio, aPTT Activated partial thromboplastin time, MMP Matrix metalloproteinase, TIMP Tissue inhibitor of matrix metalloproteinases