Figure 2.
Mechanical loading of cartilage microfracture models in culture. (A) Schematic image of MechanoActive Transduction and Evaluation (MATE) bioreactor. The electromagnetic coil motor (VCM) raises the plunger and culture dish, thereby compressing specimens onto impermeable posts. Adapted with permission from Lujan TJ, Wirtz KM, Bahney CS, Madey SM, Johnstone B, Bottlang M. A novel bioreactor for the dynamic stimulation and mechanical evaluation of multiple tissue-engineered constructs. Tissue Eng Part C Methods. 2011;17(3):367-374.28 (B) The compact-sized MATE readily fits into standard incubators. (C) Rotatory cell culture system in the incubator.