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. 2019 Jul 11;10:735. doi: 10.3389/fneur.2019.00735

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Copyright © 2019 Gingele, Hümmert, Alvermann, Jendretzky, Bönig, Brieskorn, Schwenkenbecher, Sühs, Müschen, Osmanovic, Schreiber-Katz, Stangel, Petri and Skripuletz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell distribution of leukocyte subpopulations during treatment with nusinersen. Respective cell populations are given as proportion of total leukocytes in percentage with mean ± standard error of the mean (SEM) (A). Ratio between share of monocytic cells (including monocytes and different forms of macrophages termed as “phagocytes”) and lymphocytes is depicted at different time points of nusinersen therapy (B). Dot plots show mean ± SEM. LP, lumbar puncture; LY, lymphocytes; PC, plasma cells; MO, monocytes; MA, macrophages; NP, nusinophages; SI, siderophages; ES, erythrosiderophages; E, erythrophages; NG, neutrophil granulocytes; EG, eosinophil granulocytes; BG, basophil granulocytes.