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. Author manuscript; available in PMC: 2019 Sep 13.
Published in final edited form as: J Med Chem. 2018 Aug 30;61(17):7877–7891. doi: 10.1021/acs.jmedchem.8b00827

Figure 4.

Figure 4.

Compound 13f inhibits tumor growth in vivo. (A) A375 xenograft model in nude mice. The graph represents mean tumor volume ± SEM (n = 8). (B) Individual tumor final volumes ± SEM. (C) Tumor weights ± 95% CI. Statistical significance for tumor volume and weight was determined by one-way ANOVA analysis followed by Dunnett’s multiple comparison test for the treatment group compared with the corresponding results of the control group. (D) Mouse body weights are represented as a percent of weight change compared to initial weight ± SEM (***p < 0.001, ****p < 0.0001).