Table 1.
In Vitro Growth Inhibitory Effects (nM) of VERU-111 Analogues Modifying the TMP Moiety
| ||||
|---|---|---|---|---|
| compound | R | A375 | M14 | RPMI7951 |
| 13a |
|
158.7 ± 16.4 | 118.8 ± 14.3 | 213.7 ± 17.1 |
| 13b |
|
190.6 ± 16.8 | 154.6 ± 10.4 | 235.6 ± 19.3 |
| 13c |
|
21.0 ± 1.6 | 11.3 ± 0.8 | 29.2 ± 1.7 |
| 13d |
|
3.5 ± 0.4 | 5.6 ± 0.6 | 5.6 ± 0.5 |
| 13e |
|
32.2 ± 3.4 | 38.2 ± 3.5 | 47.7 ± 3.9 |
| 13f |
|
1.1 ± 0.1 | 1.2 ± 0.2 | 3.3 ± 0.3 |
| 19 |
|
17.1 ± 1.1 | 13.8 ± 0.9 | 34.8 ± 2.2 |
| 25 |
|
6.1 ± 0.2 | 6.1 ± 0.2 | 8.8 ± 0.5 |
| VERU-111 | 8.1 ± 1.6 | 5.6 ± 0.9 | 7.2 ± 0.9 | |