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. Author manuscript; available in PMC: 2019 Jul 18.
Published in final edited form as: J Am Chem Soc. 2019 Jan 22;141(5):1842–1846. doi: 10.1021/jacs.8b11852

Figure 1.

Figure 1

(a) Proposed mechanism of pyridine synthases. Steps potentially influenced by base (1–3) are highlighted. (b) Thiopeptides thiocillin (left) and thiomuracin (right) and their precursor peptide sequences (c, d). Orange regions highlight pyridine synthase recognition sequences used in this work. Core residues in red are converted to Dhas/Dhbs and residues in blue are converted to thiazoles.