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. 2019 Jul 16;11:1758835919864247. doi: 10.1177/1758835919864247

Table 3.

Anticancer agents targeting to TIMP-3.

Agent name Targeting cancer Anticancer function Reference
Natural products
Andrographolide Breast cancer Antiangiogenesis Dai et al.93
Diallyl disulfide Gastric cancer Inhibit migration and invasion Su et al.135
EGCG Breast cancer Inhibit invasion Deb et al.136
Arctigenin Prostate cancer Inhibit tumor growth Wang et al.137
Mithramycin A Lung cancer Inhibit metastasis Lin et al.138
Synthetic products
NucAnt 6L Melanoma Inhibit invasion Destouches et al.140
p700 Breast cancer Inhibit tumor growth and angiogenesis Chen et al.141
lncRNA Diffuse large B-cell lymphoma Induce apoptosis and inhibit tumor growth Su et al.142
TAPI-0 AML Inhibit AML cell-induced STNK cell abnormalities Arriga et al.143
Epigenetic agents
SGI-1027 Multiple cancers Block DNMT1 and reactivate TIMP-3 Datta et al.144
MPT0G013 Colon cancer Inhibit angiogenesis, tumor growth, metastasis Wang et al.145
decitabine AML Enhance the lytic activity of NK cells Raneros et al.131

DNMT1, DNA methyltransferase 1; EGCG, epigallocatechin-3-gallate; NK, natural killer; p700, synthetic peptide derived from N-terminal domain of TIMP-3; STNK, short-term natural killer.