Table 4.
The regulators encoding genes affected by both constitutive topA-downregulation and topA-upregulation (based on RNA-Seq data; log2-fold >1.5; p < 0.05).
| Gene | Locus | Normalized expression in the wild type∗ | Log2-fold change topA-downregulation | Log2-fold change topA-upregulation | Description |
|---|---|---|---|---|---|
| Regulators | |||||
| sco3435 | 14 | 1.72 | 1.58 | Transcriptional regulator | |
| sco4214 | 2429 | -6.55 | -6.60 | AbaA-like regulatory protein | |
| xlnR | sco4215 | 820 | -2.05 | -2.20 | GntR family transcriptional regulator |
| sco4671 | 21 | 2.31 | 2.08 | LysR family transcriptional regulator | |
| sco4673 | 56 | 3.20 | 2.35 | DeoR family transcriptional regulator | |
| sco5656 | 2804 | -1.80 | -2.15 | Transcriptional regulator | |
| lexA | sco5803 | 240 | 2.04 | 1.62 | LexA repressor |
| nsdB | sco7252 | 118 | -1.67 | -2.80 | Regulatory protein |
| TCSs | |||||
| sco4667 | 12 | 9.75 | 8.93 | Two-component system sensor kinase | |
| sco4668 | 67 | 7.51 | 6.59 | Two-component system response regulator | |
| Proteases | |||||
| Lon | sco5285 | 10 | 1.89 | 1.85 | ATP-dependent protease |
| GNATs | |||||
| sco1624 | 13 | 2.51 | 2.74 | Acetyltransferase | |
| sco2379 | 12 | 2.14 | 1.87 | Acetyltransferase | |
| desC | sco2784 | 285 | -2.32 | -1.83 | Acetyltransferase |
∗Normalization by the upper quartile of gene expression.