Table 5.
DNA processing and DNA repair genes impacted by constitutive topA-downregulation (based on RNA-Seq data; log2-fold >1.5; p < 0.05).
| Gene | Locus | Normalized expression in the wild type∗ | Log2-fold change | Description |
|---|---|---|---|---|
| dnaE2 | sco1739 | 5 | 5.22 | DNA polymerase III subunit alpha |
| dinP | sco1738 | 6 | 4.84 | DNA polymerase IV |
| sco1767 | 29 | 1.92 | DNA hydrolase | |
| sco1827 | 72 | 1.51 | DNA polymerase III subunit epsilon | |
| uvrA | sco1958 | 69 | 1.89 | Exconuclease ABC subunit A |
| sco1969 | 67 | 1.88 | DNA-methyltransferase | |
| sco2863 | 18 | 1.98 | Helicase | |
| sco3434 | 27 | 2.01 | DNA polymerase I | |
| sco4685 | 16 | 3.43 | DEAD/DEAH box helicase | |
| xseA | sco5056 | 69 | 1.51 | Exodeoxyribonuclease VII large subunit |
| sco5183 | 12 | 1.70 | ATP-dependent DNA helicase | |
| sco5184 | 11 | 1.54 | ATP-dependent DNA helicase | |
| recX | sco5770 | 136 | 3.15 | Recombination regulator RecX |
| recA | sco5769 | 426 | 2.76 | Recombinase A |
| lexA | sco5803 | 240 | 2.04 | LexA repressor |
| sco5920 | 9 | 1.53 | DEAD/DEAH box helicase | |
| sco6719 | 2 | 3.86 | UvrA-like ABC transporter | |
| sco7522 | 7 | 2.32 | DNA ligase | |
∗Normalization by the upper quartile of gene expression.