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. Author manuscript; available in PMC: 2020 Jun 4.
Published in final edited form as: J Am Coll Cardiol. 2019 Jun 4;73(21):2722–2737. doi: 10.1016/j.jacc.2019.03.476

Central Illustration. Human Induced Pluripotent Stem Cell-Derived Endothelial Cells for evaluating e-cigarette risk.

Central Illustration.

Mechanistic overview by which e-cigarette use might case acute endothelial dysfunction. Exposure of endothelial cells to e-cigarette flavorings or serum of e-cigarette users leads to endothelial dysfunction associated with increased apoptosis, ROS, and inflammation. IL-6 = interleukin-6; ICAM-1 = intracellular adhesion molecule-1; MCSF = macrophage colony-stimulating factor; MCP-1 = monocyte chemoattractant protein-1.