. Author manuscript; available in PMC: 2019 Jul 18.

Published in final edited form as: Genes Chromosomes Cancer. 2017 Mar 31;56(6):484–492. doi: 10.1002/gcc.22452

TABLE 1.

Size and range of complete germline deletion of FH in HLRCC patients

UOB family	FH deletion	Size of deletion	Additional deleted/partially deleted genes	Minimum range of deletion (GRCh37/hg19)
UOB family	FH deletion	Size of deletion	Additional deleted/partially deleted genes	Start^a	Finish^a
UOB-4428	Complete	~4.74 Mb	RYR2, ZP4, CHRM3, FMN2, GREM2, RGS7, KMO, OPN3, CHML, WDR64, EXO1, PLD5	Chr1:237,941,801	Chr1:242,677,983

UOB-4366	Complete	~2.40 Mb	CHRM3, FMN2, GREM2, RGS7, KMO, OPN3, CHML, WDR64, EXO1, PLD5	Chr1:239,927,943	Chr1:242,322,958

UOB-3952	Complete	~2.25 Mb	CHRM3, FMN2, GREM2, RGS7, KMO, OPN3, CHML, WDR64, EXO1, PLD5	Chr1:240,071,458	Chr1:242,322,958

UOB-1126	Complete	~1.83 Mb	RGS7, KMO, OPN 3, CHML, WDR64, EXO1, PLD5	Chr1:240,845,554	Chr1:242,677,983

UOB-4636	Complete	~1.25 Mb	RGS7, KMO, OPN3, CHML, WDR64, EXO1	Chr1:240,849,498	Chr1:242,094,956

UOB-4087	Complete	~981 kb	RGS7, KMO, OPN3, CHML, WDR64	Chr1:240,918,766	Chr1:241,900,239

UOB-1815	Complete	484 kb^b	RGS7, KMO, OPN3, CHML, WDR64	Chr1:241,465,096^b	Chr1:241,949,083^b

UOB-4391	Complete	249 kb^b	KMO, OPN3, CHML, WDR64	Chr1:241,650,802^b	Chr1:241,900,239^b

UOB-4515	Complete	Unknown	N/A	N/A	N/A

UOB-4431	Complete	Unknown	N/A	N/A	N/A

UOB-4861	Complete	Unknown	N/A	N/A	N/A

UOB-4862	Partial	Unknown	N/A	Exon 7	Downstream of Exon 10

UOB-4838	Partial	4.01 kb^b	None	Chr1: 241,683,108^b	Chr1: 241,684,038^b

Start and Finish coordinates represent the position of the first and last CGH array probes lost respectively and demonstrate the minimum range of the deletion based on CGH array probes.

Deletion mapped to the exact base pair breakpoint.