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. 2019 Jul 11;10:879. doi: 10.3389/fphys.2019.00879

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Copyright © 2019 González-González, González, Rueda, Alonso-González, Menéndez-Menéndez, Gómez-Arozamena, Martínez-Campa and Cos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of melatonin on radiation-induced changes on mRNA expression of some of the main pro-angiogenic factors, ANG-1 (A), ANG-2 (B), and VEGF (C). HUVECs treated for a week with melatonin 1 mM or its diluent were co-cultured with MCF-7 cells, irradiated and incubated for 4 h, as indicated in material and methods. The total cellular RNA was isolated from cells and reverse transcribed. cDNA was subjected to PCR using specific primers for VEGF, ANG-1, ANG-2, or S14. Data are expressed as the percentage of the control group (mean ± SEM). C, control; M, melatonin; and R, radiation. a, p < 0.001 vs C; b, p < 0.001 vs R; and c, p < 0.05 vs M.