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. 2019 Jul 11;10:879. doi: 10.3389/fphys.2019.00879

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Copyright © 2019 González-González, González, Rueda, Alonso-González, Menéndez-Menéndez, Gómez-Arozamena, Martínez-Campa and Cos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of radiation in the presence or not of melatonin 1 mM on the genes selected for analysis by specific RT-PCR: (A) FGFR3, IGF-1, JAG1, TGFα, KDR, and ANPEP as angiogenic growth factors, (B) MMP14 and TIMP1 as extracellular matrix molecules, (C) CXCL6, NOS3, CCL2, ERK1, ERK2, and AKT1 as cytokines and other angiogenic factors. Data are expressed as the percentage of the control group (Mean ± SEM). C, control; M, melatonin; and R, radiation. a, p < 0.05 vs C; b, p < 0.001 vs C; c, p < 0.05 vs R; and d, p < 0.001 vs R.