Table 2.

Codons subjected to positive selection in the coiled coil (CC) domain.

Codon position	Amino acid substitutions*	BLOSUM62† scores range	Position in the helix‡	FEL dN–dS§	FEL P value¶
13	M, V	1	a	0.85	0.08
29	I, K, R	−3 to 2	c	1.49	0.06
48	D, M, I, A, V	−3 to 1	g	0.99	0.06
69	C, L	−1	d	1.95	0.04
73	V, M, A	−1 to 1	a	0.73	0.09
97	P, S	−1		0.82	0.10
101	I, C, F	−2 to 0	a	2.74	0.03
134	A, V	0		1.37	0.04
147	C, H, F, E	−4 to 0		3.29	0.09

FEL, fixed‐effects likelihood.

^* Amino acid substitutions represented by the single letter code.

^† Range of BLOSUM62 score substitutions in the codon (Henikoff and Henikoff, 1992).

^‡ Positions of the codon in the helix. a and d, intramolecular dimerization positions; c and g, solvent‐exposed positions.

^§ FEL dN–dS is the difference between nonsynonymous and synonymous substitutions as calculated by the DataMonkey server (Pond and Frost, 2005).

^¶ FEL P value is the probability that the codon is under positive selection.