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. 2019 Jul 18;14(7):e0219390. doi: 10.1371/journal.pone.0219390

Fig 5. Involvement of sentrin-specific protease 7 (SENP7) and K(lysine) acetyltransferase 2B (KAT2B) in networks of protein–chemotherapy drug interactions, cisplatin, doxorubicin, cyclophosphamide and piroxicam.

Fig 5

Interactions of SENP7 with cisplatin (A), SENP7 with doxorubicin (B), SENP7 with cyclophosphamide and piroxicam (C), KAT2B with cisplatin (D), KAT2B with doxorubicin (E), KAT2B with cyclophosphamide and piroxicam (F) were exhibited. Red circles: SENP7 and KAT2B. Abbreviations: ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), ataxia telangiectasia mutated (ATM), ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2), v-akt murine thymoma viral oncogene homolog 1 (AKT1), caspase 3 (CASP3), c-jun (JUN), CREB binding protein (CREBBP), cytochrome P450 family 2 subfamily B member 6 (CYP2B6), cytochrome P450 family 2 subfamily C member 9 (CYP2C9), cytochrome P450 family 2 subfamily C member 19 (CYP2C19), cytochrome P450 family 2 subfamily D member 6 (CYP2D6), cytochrome P450 family 3 subfamily A member 4 (CYP3A4), E1A binding protein p300 (EP300), epidermal growth factor receptor (EGFR), v-myc myelocytomatosis viral oncogene homolog (MYC), DNA excision repair protein ERCC-1, endonuclease non-catalytic subunit (ERCC1), Harvey rat sarcoma viral oncogene homolog (HRAS), myogenic differentiation 1 (MYOD1), nuclear receptor coactivator 3 (NCOA3), poly [ADP-ribose] polymerase 1 (PARP-1), prostaglandin-endoperoxide synthase 1 (PTGS1), prostaglandin-endoperoxide synthase 2 (PTGS2), sirtuin 3 (SIRT3), solute carrier family 30 (zinc transporter), member 6 (SLC30A6), suppressor of Ty 3 homolog (S. cerevisiae) (SUPT3H), SMT3 suppressor of mif two 3 homolog 1 (SUMO1), SMT3 suppressor of mif two 3 homolog 2 (SUMO2), transcriptional adaptor 2A (TADA2A), transcriptional adaptor 3 (TADA3), TAF10 RNA polymerase II (TAF10), topoisomerase (DNA) II alpha (TOP2A), transformation/transcription domain-associated protein (TRRAP), tumor protein p53 (TP53), ubiquitin-conjugating enzyme E2I (UBE2I).