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. 2019 Jul 18;14(7):e0219390. doi: 10.1371/journal.pone.0219390

Fig 6. Involvement of peroxisome proliferator-activated receptor gamma, coactivator-related 1 (PPRC1) and deltex 3-like (DTX3L) in networks of protein–chemotherapy drug interactions, cisplatin and doxorubicin.

Fig 6

Interactions of PPRC1 with doxorubicin (A), PPRC1 with cisplatin (B) and DTX3L with cisplatin (C) are shown. Red circles: PPRC1 and DTX3L. Abbreviations: ABCB1, ATP-binding cassette, sub-family B, member 1; ABCC1, ATP-binding cassette, sub-family C, member 1; ABCG2, ATP-binding cassette, sub-family G, member 2; AKT1, v-akt murine thymoma viral oncogene homolog 1; ATM, ataxia telangiectasia mutated; CASP3, caspase 3; EGFR, epidermal growth factor receptor; ERCC1, excision repair cross-complementing rodent repair deficiency, complementation group 1; HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog; JUN, jun proto-oncogene; MYC, v-myc myelocytomatosis viral oncogene homolog; nuclear respiratory factor 1 (NRF1), PARP1, poly (ADP-ribose) polymerase 1; PARP9, poly (ADP-ribose) polymerase family, member 9; SIRT3, sirtuin 3; TOP2A, topoisomerase II alpha; TP53, tumor protein p53.