Table 2. Comparison of glycemic profile between normal ALT and high ALT in CFRD patients.
| All CFRD patients N = 39 |
Normal ALT (< 25 U/L) N = 18 |
High ALT (≥ 25 U/L) N = 21 |
p-value |
|
|---|---|---|---|---|
| Age (years) | 26.4 ± 7.2 | 25.4 ± 7.9 | 27.2 ± 6.7 | 0.403 |
| Sex (% men) | 59.0 | 27.8 | 85.7 | < 0.001* |
| ALT (U/L) | 29.0 ± 13.2 | 18.1 ± 3.6 | 38.4 ± 11.0 | < 0.001 |
| OGTT glucose measure (mmol/L) | ||||
| T0 min | 6.3 ± 1.2 | 5.8 ± 0.8 | 6.6 ± 1.4 | 0.037 |
| T30 min | 11.4 ± 2.6 | 10.4 ± 1.8 | 12.2 ± 3.0 | 0.027 |
| T60 min | 15.5 ± 3.4 | 14.0 ± 2.6 | 16.7 ± 3.6 | 0.011 |
| T90 min | 15.9 ± 3.5 | 14.2 ± 2.1 | 17.3 ± 3.9 | 0.004 |
| T120 min | 14.3 ± 2.5 | 13.3 ± 2.5 | 15.1 ± 2.3 | 0.031 |
| AUC0-120min | 1592.1 ± 398.9 | 1445.2 ± 208.1 | 1713.0 ± 337.5 | 0.005 |
| HbA1c (%) | 6.33 ± 0.82 | 6.26 ± 0.63 | 6.40 ± 0.97 | 0.602 |
| Insulin sensitivity (Stumvoll index) | 0.037 00B1 0.024 | 0.046 ± 0.021 | 0.030 ± 0.25 | 0.045 |
| HOMA-IR | 3.07 ± 1.62 | 2.49 ± 1.32 | 3.59 ± 1.72 | 0.040 |
ALT: alanine aminotransferase; OGTT: oral glucose tolerance test; AUC0-120min: area under the curve from T0 to T120 min OGTT; HbA1c: glycosylated hemoglobin; HOMA-IR: insulin resistance index.
Data are presented as mean ± SD. Student’s t-test was performed to compare groups’ means.
*Chi square test was performed for categorical variables. Statistical significance was set at p ≤ 0.05. Values in bold represent significant p-values.