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. 2019 Jul 18;14(7):e0219942. doi: 10.1371/journal.pone.0219942

Table 2. The odds ratios of high blood pressure at age of 7 years with different concentrations of total serum bilirubin at 48h after birth.

Total serum bilirubin High blood pressure at 7 years old
n/N (%) Model 1 Model 2 Model 3
OR 95% CI OR 95% CI OR 95% CI
Preterm Infants < 3mg/dl 55/613 (9.0) 1 1 1
≥ 3mg/dl, < 6mg/dl 148/1270 (11.7) 1.34 0.97, 1.85 1.36 0.98, 1.89 1.36 0.98, 1.91
≥ 6mg/dl, < 9mg/dl 202/1711 (11.8) 1.36 0.99, 1.86 1.35 0.98, 1.85 1.36 0.99, 1.86
≥ 9mg/dl, < 12mg/dl 136/951 (14.3) 1.69 1.22, 2.36 1.55 1.10, 2.19 1.54 1.09, 2.21
≥ 12mg/dl 169/1180 (14.3) 1.70 1.23, 2.34 1.42 1.01, 2.00 1.42 1.00, 2.02
Term Infants < 3mg/dl 744/6452 (11.5) 1 1 1
≥ 3mg/dl, < 6mg/dl 1197/10510 (11.4) 0.99 0.90, 1.09 1.00 0.91, 1.11 1.01 0.91, 1.12
≥ 6mg/dl, < 9mg/dl 1005/9248 (10.9) 0.94 0.85, 1.03 0.97 0.88, 1.08 0.96 0.85, 1.07
≥ 9mg/dl, < 12mg/dl 392/3315 (11.8) 1.03 0.90, 1.17 1.07 0.93, 1.22 1.07 0.91, 1.25
≥ 12mg/dl 226/2294 (11.6) 1.01 0.87, 1.17 1.02 0.88, 1.19 1.00 0.85, 1.24

Model 1: crude odds ratios; Model 2: Adjusted for race (white, black, and other race), sex (male and female), birth weight (< 2500g, 2500g–4000g and ≥4000g), gestational age (as a categorical variable), transfusion (yes and no), hypertensive disorders during pregnancy (none, moderate, and severe), maternal smoking (0, 1–19 and 20 cigarette per day during pregnancy) and socioeconomic status (comprised of 5 categories as assessed by the original CPP investigators); Model 3: adjusted for the same factors as model 2 in Generalized Estimating Equation mode