. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Cancer Causes Control. 2019 May 18;30(7):757–765. doi: 10.1007/s10552-019-01183-1

Table 2.

Association between 25(OH)D-associated SNPs in GWAS (Tier 1 SNPs), an additive genetic risk score, and plasma 25(OH)D levels among patients with metastatic colorectal cancer

Genetic variant^a	Position (nearest gene)	Major/minor allele	MAF	Risk allele	Unadjusted		Multivariable^b
Genetic variant^a	Position (nearest gene)	Major/minor allele	MAF	Risk allele	Coefficient	P	Coefficient	P
rsl993116	CYP2R1	C/T	0.38	С	−2.31	0.0004	−1.76	0.005
rs6013897	CYP24A1	T/A	0.23	A	−1.89	0.02	−1.39	0.06
rsl2785878	DHCR7	T/G	0.32	G	−1.38	0.04	−0.38	0.58
rsl1234027	NADSYN1	G/A	0.19	A	−1.76	0.03	−1.12	0.15
rs2282679	GC	A/C	0.26	С	−0.96	0.19	−1.13	0.11
Genetic risk score	-	-	-	-	−1.31	<0.0001	−0.93	0.0009

25(OH)D 25-hydroxyvitamin D₃, GWAS genome-wide association studies, MAF minor allele frequency, SNP single-nucleotide polymorphism

Additive effect of a risk allele (i.e., associated with lower 25(OH)D levels) on 25(OH)D levels (continuous in ng/mL)

Adjusted for age (continuous), sex (female, male), race/ethnicity (white, black, other, unknown/missing), and season of blood collection (summer, fall, winter, spring)