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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Hypertension. 2019 Jun 3;74(1):63–72. doi: 10.1161/HYPERTENSIONAHA.119.12651

Figure 2.

Figure 2.

(A) Real-time PCR indicating the fold change of TACE mRNA in subfornical organ (SFO) and hypothalamic paraventricular nucleus (PVN) in sham-operated (Sham) and heart failure (HF) rats. (B and C) Western blot analysis showing the expression of TACE protein in SFO and PVN in Sham and HF rats. (D) TACE activity in the SFO and PVN in Sham and HF rats treated with ICV vehicle or TAPI-1. Values are expressed as mean ± SEM. Western data is normalized to β-actin. * p<0.05, compared to Sham (n=6 in each group). † p<0.05, compared with HF + vehicle (VEH).