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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Hypertension. 2019 Jun 3;74(1):63–72. doi: 10.1161/HYPERTENSIONAHA.119.12651

Figure 5.

Figure 5.

Representative tracings showing the effects of intracerebroventricular (ICV) TACE inhibitor TAPI-1 on blood pressure (BP), heart rate (HR) and renal sympathetic nerve activity (RSNA) in (A) sham-operated (Sham) and (B) heart failure (HF) rats. BP, mmHg; HR, beats/min (bpm): RSNA, windowed (spikes/s) and integrated (mV) activity. (C), Grouped data showing the change (Δ) from baseline in mean blood pressure (MBP, mmHg), HR (bpm) and RSNA (%) elicited by ICV TAPI-1 in Sham and HF rats. Integrated RSNA was used for data analysis. Values are expressed as means ± SEM (n=6 in each group). * p<0.05, compared with baseline; † p<0.05 compared with Sham.