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. Author manuscript; available in PMC: 2019 Jul 18.
Published in final edited form as: Gene. 2016 Apr 8;590(2):193–200. doi: 10.1016/j.gene.2016.03.048

Fig. 2.

Fig. 2.

Schematic representation of the role of JDP2 on oxidative stress and antioxidation. Various stresses regulate the expression of JDP2. JDP2 associates with sMaf family and Nrf2 to induce the ARE response of variety of antioxidation response related genes, and at the same time JDP2 inhibits the ROS production to maintain the ROS homeostasis against oxidative stress (Tanigawa et al., 2013; Tanigawa and Yokoyama, 2013). ROS are generated by the oxidation of lipid and DNA via ER stress. Therefore, JDP2 controls the balance of ROS production through the transcriptional control with respective partner molecules for cytoprotection.