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. Author manuscript; available in PMC: 2019 Jul 18.
Published in final edited form as: Gene. 2016 Apr 8;590(2):193–200. doi: 10.1016/j.gene.2016.03.048

Fig. 3.

Fig. 3.

Putative models of JDP2 to play the double-edge swords to control the transcription and epigenetic regulation. Possible positive and negative transcriptional regulations of JDP2 are presented in this model. JDP2 might form the complex with sMafK and/or Nrf2 and bind to the ARE element to increase the transcription of ARE related genes (Tanigawa et al., 2013) via recruitment of CBP/p300 coactivator-dependent Nrf2 acetylation (Kawai et al., 2011) or possibly histone acetylation. On the other hand, JDP2 might recruit the HDAC family (Jin et al., 2002; Darlyuk-Saadon et al., 2012; Maruyama et al., 2012) or INHAT activity (Jin et al., 2006) to repress the transcription of cell cycle related genes (Pan et al., 2010).