Figure 1.

Characterizing the response to androgen deprivation in an orthotopic mouse model. A) Experimental ADT time line and tissue procurement. B) Survival rate of mice in androgen intact and deprived (5 mg cohort) groups. Data were analyzed by log-rank test. ***p<0.001. C) Representative genes regulated in Clone 1 tumors by androgen deprivation. D) Correlation analysis of primary tumor sections in androgen intact and androgen deprived groups. Sections were dual stained for Ki67 and pAKT and scored using an automated platform. n=5 mice / group. The Pearson r values are 0.59 and 0.32 for androgen intact and androgen deprived, respectively.