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. 2019 Jul 8;8:e46156. doi: 10.7554/eLife.46156

Figure 4. Visual Recognition Memory: Structural/Functional correlates.

Figure 4.

(a) mean GM volume of the left HPC cluster correlated with the mean rsALFF of the PCC cluster across patients; (b) visual recognition memory scores correlated across patients with their mean rsALFF in the PCC cluster, surviving correction for multiple testing for the 13 structural/functional abnormalities examined (r = 0.54, p-corr = 0.014); the mediation analysis demonstrates that this effect held over and above the correlation of PCC rsALFF with the mean GM volume of the left HPC cluster; (c) mean GM volume of the left HPC cluster correlated with visual recognition memory scores across patients, but did not survive correction for multiple testing (r = 0.45, p-corr = 0.072); however, the mediation analysis demonstrated that this relationship did not hold over and above the correlation of the mean GM volume of the left HPC cluster with the mean PCC rsALFF; there was only an indirect effect of reduced HPC GM volume on visual recognition memory (within parenthesis: 95% confidence intervals); GM: gray matter; HPC: hippocampus; L: left (hemisphere); MAP: Memory and Amnesia Project; OPTIMA: Oxford Project To Investigate Memory and Aging; p: significance values are presented at uncorrected levels; PCC: posterior cingulate cortex; rsALFF: resting-state amplitude of low frequency fluctuations; TIV: total intracranial volume; VBM: voxel-based morphometry; z: memory scores are averaged age-scaled and standardized scores of participants’ performance in the subtests of interest; z-res: GM volumes from VBM clusters are residualized against age, sex, scan source (MAP, OPTIMA), and TIV across participants; mean rsALFF values are residualized across participants against age and sex.

Figure 4—source data 1. This spreadsheet contains the mean GM volume of the left HPC VBM cluster and the mean rsALFF in the PCC (z-res) and the visual recognition memory composite scores (z) of healthy controls and patients that are plotted in Figure 4; GM: gray matter; HPC: hippocampus; MAP: Memory and Amnesia Project; OPTIMA: Oxford Project To Investigate Memory and Aging; PCC: posterior cingulate cortex; rsALFF: resting-state amplitude of low-frequency fluctuations; VBM: voxel-based morphometry; z: memory scores are averaged age-scaled and standardized scores of participants’ performance in the subtests of interest; z-res: GM volumes from VBM clusters are residualized against age, sex, scan source (MAP, OPTIMA), and TIV across participants; mean rsALFF is residualized against age and sex across participants. These data can be opened with Microsoft Excel or with open-source alternatives such as OpenOffice.
elife-46156-fig4-data1.xlsx (15.1KB, xlsx)
DOI: 10.7554/eLife.46156.012