Table 3. Volumetry of MTL and subcortical structures in autoimmune LE patients.
| Structure | Controls | Patients | Mean % reduction | F | Partial η2 | p-corr | ||
|---|---|---|---|---|---|---|---|---|
| Mean (mm3) | SD (mm3) | Mean (mm3) | SD (mm3) | |||||
| R HPC | 3648.99 | 459.59 | 2733.87 | 751.09 | −25.08 | 63.38 | 0.390 | <0.0005 |
| L HPC | 3439.48 | 431.91 | 2671.18 | 710.65 | −22.34 | 46.02 | 0.317 | <0.0005 |
| R ERC | 1602.69 | 324.07 | 1254.97 | 404.70 | −21.70 | 10.76 | 0.119 | 0.0308 |
| L ERC | 1508.83 | 326.07 | 1200.18 | 432.07 | −20.46 | 9.48 | 0.106 | 0.0534 |
| R Thalamus | 7407.51 | 762.15 | 7072.79 | 845.09 | −4.52 | 8.23 | 0.077 | 0.0900 |
| L Thalamus | 7633.09 | 788.11 | 7194.76 | 797.73 | −5.74 | 15.41 | 0.135 | 0.0034 |
| R PRC | 1791.42 | 378.97 | 1561.61 | 403.86 | −12.83 | 7.11 | 0.082 | 0.1575 |
| L PRC | 1812.50 | 523.31 | 1601.39 | 478.78 | −11.65 | 2.88 | 0.035 | >0.9999 |
| R PHC | 1900.73 | 423.85 | 1665.68 | 331.28 | −12.37 | 6.36 | 0.074 | 0.2240 |
| L PHC | 2016.52 | 435.92 | 1851.53 | 445.52 | −8.18 | 1.53 | 0.019 | >0.9999 |
| R AMG | 1395.67 | 267.38 | 1313.76 | 406.51 | −5.87 | 5.15 | 0.060 | 0.3899 |
| L AMG | 1321.96 | 217.40 | 1268.47 | 384.22 | −4.05 | 4.43 | 0.053 | 0.5320 |
| R Nacc | 339.42 | 107.77 | 318.53 | 109.69 | −6.16 | 0.25 | 0.003 | >0.9999 |
| L Nacc | 433.79 | 127.41 | 381.89 | 153.66 | −11.96 | 3.70 | 0.036 | 0.7410 |
| R TPC | 4558.60 | 846.26 | 4520.16 | 1026.08 | −0.84 | 0.12 | 0.002 | >0.9999 |
| L TPC | 4331.40 | 742.35 | 4512.95 | 795.76 | 4.19 | 1.90 | 0.023 | >0.9999 |
| R Putamen | 4332.54 | 548.04 | 4157.00 | 630.21 | −4.05 | 0.85 | 0.008 | >0.9999 |
| L Putamen | 4382.39 | 705.40 | 4151.89 | 662.93 | −5.26 | 1.67 | 0.017 | >0.9999 |
| R Caudate | 3403.96 | 440.42 | 3369.16 | 453.63 | −1.02 | 0.06 | 0.001 | >0.9999 |
| L Caudate | 3211.40 | 438.40 | 3134.26 | 497.42 | −2.40 | 0.12 | 0.001 | >0.9999 |
| R Pallidum | 1705.61 | 260.63 | 1630.00 | 251.08 | −4.43 | 0.90 | 0.009 | >0.9999 |
| L Pallidum | 1720.40 | 297.86 | 1661.13 | 308.18 | −3.45 | 0.41 | 0.004 | >0.9999 |
| brainstem | 22119.06 | 2258.25 | 21931.42 | 2647.93 | −0.85 | 0.23 | 0.002 | >0.9999 |
Volumetry of manually and automatically delineated MTL and other subcortical structures of all patients (n = 38). Volumes for each structure are compared between patients and controls, using age, sex, TIV, and scan source (MAP, OPTIMA) as between-subjects covariates in a series of univariate ANCOVAs; AMG: amygdala; ANCOVA: analysis of covariance; ; ERC: entorhinal cortex; HPC: hippocampus; L: left hemisphere; MAP: Memory and Amnesia Project; MTL: medial temporal lobe; Nacc: nucleus accumbens; OPTIMA: Oxford Project To Investigate Memory and Aging; p-corr: p values are adjusted with the Holm-Bonferroni sequential correction method for multiple comparisons (n = 23); PHC: parahippocampal cortex; PRC: perirhinal cortex; R: right hemisphere; SD: standard deviation; TIV: total intracranial volume; TPC: temporopolar cortex.