Table 5. Summary of relationships between memory impairment and structural/functional abnormalities across patients.
Memory composite score | Effects of HPC atrophy | |
---|---|---|
Anterograde retrieval | Verbal recognition | Does not explain additional variance beyond that explained by inter-HPC rsFC reduction |
Visual Recognition | Fully mediated by PCC rsALFF reduction | |
Verbal Recall | ||
Visual Recall | ||
Anterograde Retention (Visual Forgetting) | Direct effect - not mediated by extra-HPC abnormalities | |
Remote Autobiographical Memory | Fully mediated by thalamic volume reduction |
HPC: hippocampus; PCC: posterior cingulate cortex; rsALFF: resting-state amplitude of low frequency fluctuations; rsFC: resting-state functional connectivity.