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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Alcohol. 2019 Jan 18;79:93–103. doi: 10.1016/j.alcohol.2019.01.006

Figure 2. Ethanol consumption, water consumption, and quinine resistant drinking after the first 7-week period of two-bottle choice drinking.

Figure 2.

Measurement of ethanol consumption at the 30 min (A) and 24 hr (B) time points during the first 7-week period of intermittent 2BC drinking. Both AIR control and AIE exposed rats significantly escalated consumption over drinking days. There was no significant difference between AIR and AIE exposed rats in the average daily consumption of ethanol across the entire drinking period (bar graph insets). The volume of water consumed by AIR and AIE exposed rats at 30 min (C) and 24 hr (D) time points also did not differ significantly. Both AIR and AIE groups elevated their 30 min water intake across days, whereas 24 hr water intake progressively decreased over time and showed little variability. Average intake was not significantly different between AIR and AIE exposed rats at either time-point (bar graph insets). Following the first 7-week period of 2BC drinking, assessment of quinine suppression of ethanol intake revealed a significant decrease in consumption relative to baseline that was only observed at the highest concentration (100 mg/L) of quinine tested at both the 30 min (E) and 24 hr (F) time-points. There were no significant differences in intake between AIR and AIE at any concentration of quinine adulterated ethanol. Baseline drinking represented consumption during the week preceding initiation of quinine testing. Asterisks indicate significantly different from 0 mg/L. *p < 0.05; n = 7-8/group.