Table 3.
Survival analyses—multivariate analyses of Paget disease
| Variable | Category/Mean | Hazard ratio | 95% Confidence interval | P‐value | |
|---|---|---|---|---|---|
| PD‐IDC | Age at diagnosis (years) | Mean: 60.07 y | 1.034 | 1.022‐1.045 | <0.001 |
| Race | White | 1 | Referent | 0.018 | |
| Black | 1.285 | 0.842‐1.961 | |||
| Hispanic/Other/Unknown | 0.618 | 0.410‐0.931 | |||
| Tumor location | Central/NAC | 1 | Referent | 0.024 | |
| Upper inner quadrant | 1.619 | 0.914‐2.867 | |||
| Lower inner quadrant | 2.641 | 1.498‐4.656 | |||
| Upper outer quadrant | 1.399 | 0.919‐2.130 | |||
| Lower outer quadrant | 1.712 | 0.947‐3.097 | |||
| Overlapping lesion | 1.252 | 0.821‐1.909 | |||
| Tumor grade | Grade I | 1 | Referent | 0.001 | |
| Grade II | 8.125 | 1.113‐59.311 | |||
| Grade III | 13.453 | 1.869‐96.861 | |||
| Grade IV | 22.712 | 2.633‐195.932 | |||
| T | T1 | 1 | Referent | <0.001 | |
| T2 | 1.493 | 1.001‐2.226 | |||
| T3 | 3.024 | 1.844‐4.961 | |||
| T4 | 2.704 | 1.671‐4.376 | |||
| N | N0 | 1 | Referent | <0.001 | |
| N1 | 2.249 | 1.484‐3.411 | |||
| N2 | 3.763 | 2.355‐6.012 | |||
| N3 | 6.902 | 4.183‐11.389 | |||
| PD‐DCIS | Age at diagnosis (years) | Mean: 62.81 y | 1.084 | 1.052‐1.116 | <0.001 |
| T | T0 | 1 | Referent | 0.005 | |
| T1 | 0.820 | 0.271‐2.476 | |||
| T2 | 4.027 | 1.420‐11.417 | |||
| T3 | 6.674 | 1.507‐29.560 | |||
| T4 | 0.418 | 0.037‐4.730 | |||
| N | N0 | 1 | Referent | <0.001 | |
| N1 | 6.320 | 1.217‐32.817 | |||
| N2 | 27.077 | 5.035‐145.623 | |||
| N3 | 28.109 | 3.649‐216.518 |
Abbreviations: AJCC, American Joint Committee on Cancer; DCIS, ductal carcinoma in situ; IDC, invasive ductal carcinoma; NAC, nipple‐areola complex; PD‐DCIS, Paget disease with ductal carcinoma in situ; PD‐IDC, Paget disease with invasive ductal carcinoma