Table 5.
Double combination mutations detected in 32 colorectal cancer samples
| Gene 1 | Mutation 1 | Gene 2 | Mutation 2 | Sex | Age (years) | Differentiation | AJCC stage |
|---|---|---|---|---|---|---|---|
| ARAF | p.T256fs | FBXW7 | p.W307C | M | 65 | Middle to Low | NA |
| APC | p.Q1916* | MLH1 | p.T117M | M | 72 | Middle | IIA |
| KRAS | p.G12V | TP53 | p.C176F | F | 57 | Middle | IIIB |
| APC | p.Q1367* | TP53 | p.R282W | M | 61 | Middle | IIIB |
| SOX9 | p.G485fs | APC | p.R283* | F | 78 | Middle | IIA |
| APC |
p.L540fs p.R1450* |
TP53 | p.L43fs | M | 35 | Middle | IIA |
| KRAS | p.G12V | APC |
p.R564* p.L1302fs |
M | 68 | Middle | IIA |
| APC | p.Q541* | TP53 | p.M246R | F | 58 | Middle | IIA |
| APC |
p.L620fs p.E1306fs |
TP53 | p.L206* | F | 47 | Middle | I |
| APC |
p.S320* p.E1544* |
FBXW7 | p.R387C | F | 42 | Middle | IIIB |