Table 3.
Multivariable cox proportional hazards models for overall survival in patients receiving treatment for anal adenocarcinoma
| Significant characteristic | Hazard of death (95% CI) | P |
|---|---|---|
| Cox model without propensity score | ||
| Age | ||
| ≤65 | Reference | |
| >65 | 1.96 (1.62‐2.40) | <0.0001 |
| Comorbidity score | ||
| 0 | Reference | |
| 1 | 1.12 (0.91‐1.40) | 0.27 |
| ≥2 | 1.59 (1.19‐2.13) | <0.0001 |
| Surgical approach | ||
| No | Reference | |
| Yes | 0.57 (0.49‐0.66) | <0.0001 |
| Insurance | ||
| None | Reference | |
| Private | 0.61 (0.49‐0.75) | <0.0001 |
| Government | 0.74 (0.49‐1.10) | 0.13 |
| Stage group | ||
| 1 | Reference | |
| 2 | 1.08 (0.87‐1.64) | 0.48 |
| 3 | 1.65 (1.40‐1.93) | <0.0001 |
| Facility type | ||
| Community cancer program | Reference | |
| Comprehensive cancer program | 0.95 (0.86‐1.06) | 0.36 |
| Academic/Research program | 0.96 (0.73‐1.26) | 0.77 |
| Grade | ||
| 1 (well differentiated) | Reference | |
| 2 (moderately differentiated) | 1.09 (0.84‐1.44) | 0.51 |
| 3 (poorly differentiated) | 1.52 (1.27‐1.83) | <0.0001 |
| Cox model with propensity score | ||
| Age | ||
| ≤65 | Reference | |
| >65 | 2.30 (1.95‐2.71) | <0.0001 |
| Prop score | 0.31 (0.16‐0.59) | 0.0004 |
| Surgical Approach | ||
| No | Reference | |
| Yes | 0.58 (0.50‐0.68) | <0.0001 |
| Comorbid Score | ||
| 0 | Reference | |
| 1 | 1.18 (0.96‐1.46) | 0.12 |
| ≥2 | 1.64 (1.22‐2.19) | 0.0009 |
| Grade | ||
| 1 (well‐differentiated) | Reference | |
| 2 (moderately differentiated) | 1.15 (0.88‐1.50) | 0.32 |
| 3 (poorly differentiated) | 1.51 (1.26‐1.81) | <0.001 |
CI, confidence interval.