Table 4.
Survival of men with prostate cancer; by variant alleles of NBN
| Men with 657del5 mutation (n=74) | Men with 657del5 and E185Q GG genotype (n=50) | Men with 657del5 and E185Q non-GG genotype (n=24) | Men with neither genotypea) (n=2,956) | |
|---|---|---|---|---|
| Median follow-up (mo) | 90 | 90 | 87 | 106 |
| Proportion of deceased (%) | 56.8 | 62.0 | 45.8 | 43.8 |
| Median survival (mo) | 81 | 78 | 95 | 132 |
| 5-Year survival (%) | 56 | 51 | 66 | 69 |
| 10-Year survival (%) | 34 | 28 | 45 | 53 |
| HR | 1.6 | 2.0 | 1.1 | 1.0a) |
| 95% CI | 1.1-2.5 | 1.2-3.2 | 0.6-2.2 | - |
| p-value | 0.001 | 0.0001 | 0.659 | - |
Hazard ratio (HR), 95% confidence interval (CI), and p-values are calculated by log-rank test.
a)
Reference group (men with prostate cancer without 657del5 and without GG genotype of E185Q.