. 2018 Nov 21;51(3):1107–1116. doi: 10.4143/crt.2018.182

Table 4.

The association between Helicobacter pylori infection and GC risk by BMI level in the case-cohort study within the KMCC, 1993-2004

	GC development			Non-cardia GC development^a)
	Person-year	No.	Stratification HR (95% CI)^b)	Person-year	No.	Stratification HR (95% CI)^b)
BMI < 23.0 kg/m²
Never infected	2,017	12	1.00	2,017	12	1.00
Ever infected	11,398	181	2.04 (1.13-3.70)	11,366	174	1.99 (1.10-3.62)
H. pylori+CagA+	10,886	174	2.06 (1.14-3.74)	10,855	167	2.01 (1.11-3.65)
CagA+VacA+	8,494	126	2.03 (1.11-3.72)	8,468	120	1.97 (1.08-3.62)
BMI 23.0-24.9 kg/m²
Never infected	1,071	1	1.00	1,071	1	1.00
Ever infected	6,137	61	10.52 (1.44-76.67)	6,133	59	9.98 (1.37-72.78)
H. pylori+CagA+	5,895	59	10.38 (1.42-75.70)	5,891	57	9.84 (1.35-71.84)
CagA+VacA+	4,866	41	12.17 (1.63-90.02)	4,862	40	11.59 (1.55-86.69)
BMI ≥ 25.0 kg/m²
Never infected	1,358	7	1.00	1,345	6	1.00
Ever infected	8,091	70	1.73 (0.78-3.82)	8,082	69	2.02 (0.86-4.72)
H. pylori+CagA+	7,762	68	1.80 (0.81-4.00)	7,753	67	2.11 (0.90-4.94)
CagA+VacA+	6,397	51	1.73 (0.76-3.93)	6,388	50	2.03 (0.85-4.87)

GC, gastric cancer; BMI, body mass index; KMCC, Korean Multicenter Cancer Cohort; HR, hazard ratio; CI, confidence interval; CagA+, cytotoxin-associated gene A (CagA)–secreting H. pylori infection; CagA+VacA+, both CagA-secreting H. pylori and vacuolating cytotoxin A (VacA)–secreting H. pylori infection.

^a)

Non-cardia GC including unspecified cases (9% of total GC cases). The results for cardia GC development were not presented due to non-estimation of parameter estimators and their 95% CIs by sparse cardia GC cases (n=14),

^b)

Adjusted for age, sex, year of recruitment, education years (< 12 years vs. ≥ 12 years), ever smoking more or equal to 400 cigarettes (yes vs. no), and alcohol drinking status (yes vs. no).