Table 3.
Associations of 3 SNPs in MSH3 and risk of grade ≥ 2 diarrhea in rectal cancer patients
| Genotype | No. (%) |
OR (95% CI)a) | p-value | |
|---|---|---|---|---|
| Grade 0-1 diarrhea | Grade ≥ 2 diarrhea | |||
| rs12513549 | ||||
| GG | 88 (43.4) | 85 (53.1) | 1.00 (reference) | |
| GT | 93 (45.8) | 62 (38.8) | 0.69 (0.42-1.12) | 0.136 |
| TT | 22 (10.8) | 13 (8.1) | 0.49 (0.20-1.14) | 0.101 |
| GT+TT | 115 (56.6) | 75 (46.9) | 0.63 (0.39-1.00) | 0.053 |
| rs33013 | ||||
| AA | 57 (27.9) | 52 (32.3) | 1.00 (reference) | |
| AG | 105 (51.5) | 88 (54.7) | 0.88 (0.52-1.49) | 0.641 |
| GG | 42 (20.6) | 21 (13.0) | 0.38 (0.17-0.83) | 0.017 |
| AG+GG | 147 (72.1) | 109 (67.7) | 0.74 (0.44-1.22) | 0.239 |
| rs6151627 | ||||
| AA | 125 (61.3) | 84 (52.2) | 1.00 (reference) | |
| AG | 73 (35.8) | 66 (41.0) | 1.38 (0.85-2.25) | 0.192 |
| GG | 6 (2.9) | 11 (6.8) | 2.99 (0.97-10.49) | 0.067 |
| AG+GG | 79 (38.7) | 77 (47.8) | 1.50 (0.94-2.40) | 0.088 |
SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
a)
Calculated by logistic regression model and adjusted for sex, age, clinical stage, tumor grade, Karnofsky Performance Score, surgical procedure, and tumor location.