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. 2018 Dec 3;51(3):1167–1179. doi: 10.4143/crt.2018.526

Fig. 5.

Fig. 5.

Anti-tumor growth of AZD6738 alone or combination therapy. (A) In vivo efficacy of AZD6738 (25 mg/kg), cisplatin (4 mg/kg), or their combination in SNU478 xenograft model mice. **p < 0.01. T, start of treatment; CT, day of cisplatin treatment. (B) The tumors were harvested and analyzed by immunohistochemistry. Ki-67, TUNEL expression, and Chk1 phosphorylation were evaluated in the SNU478 xenograft model mice. Scale bars=50 μm. (C) Western blot assays were performed on the excised tumors from the xenograft model mice to elucidate the effects of AZD6738 and/or cisplatin.