Table 3.

Toxicity profile

Toxicity	Grade 1-2	Grade 3-4
Non-hematologic toxicities
Anorexia	11 (18.3)	0
Fatigue	20 (33.3)	1 (1.7)
Rash	9 (15.0)	1 (1.7)
Hyperpigmentation	17 (28.3)	0
Stomatitis	7 (11.7)	1 (1.7)
Hand foot syndrome	19 (31.7)	1 (1.7)
Dry skin	15 (25.0)	0
Nausea	22 (36.7)	3 (5.0)
Vomiting	2 (3.3)	1 (1.7)
Diarrhea	1 (1.7)	1 (1.7)
Constipation	10 (16.7)	0
Bowel perforation	0	2 (3.3)
Peripheral neuropathy	29 (48.3)	0
Increased CK	2 (3.3)	2 (3.3)
Increased AST/ALT	1 (1.7)	1 (1.7)
Hematologic toxicities
Neutropenia	10 (16.7)	3 (5.0)
Thrombocytopenia	3 (5.0)	0

Values are presented as number (%). CK, cytokeratin; AST, aspartate aminotransferase; ALT, alanine transaminase.