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PRRSV nsp11 inhibits ISGF3-induced ISRE promoter activity. HEK-293T cells were cotransfected with PRRSV nsp11 or its endoribonuclease activity-defective mutants (0.2 μg/well), along with porcine ISGF3 complex (STAT1/STAT2/IRF9; 0.3 μg/well), ISRE-Luc plasmid (0.04 μg/well), and pRL-TK plasmid (0.01 μg/well). After 30 h, cells were harvested for luciferase assays. *, P < 0.05.
