. 2019 Jul 17;93(15):e00305-19. doi: 10.1128/JVI.00305-19

TABLE 5.

Multivariable regression analysis of the effects of age and baseline immune parameters on the magnitude of persistent VZV-specific Th1 cells 1 year after ZVL administration in the primary cohort (n = 399)^a

Explanatory variable	1-yr IL-2⁺ SFC		1-yr IFN-γ⁺ SFC		1-yr IFN-γ⁺ IL-2⁺ SFC
Explanatory variable	RCE	P	RCE	P	RCE	P
Age	−1.35	0.02	−1.50	0.001	−1.09	0.003
Baseline responses	0.74	<0.001	0.80	<0.001	0.79	<0.001
CD4⁺ IL-10⁺	−1.46	0.9	2.72	0.78	0.77	0.92
CD8⁺ IL-10⁺	9	0.38	1.26	0.88	3.56	0.6
CD4⁺ FOXP3⁺ CD25⁺	19.11	0.68	−25.43	0.50	−7.93	0.79
CD8⁺ FOXP3⁺ CD25⁺	−37.26	0.28	−6.18	0.83	−10.35	0.65
CD4⁺ FOXP3⁺	−24.33	0.02	−10.63	0.23	−10.89	0.12
CD8⁺ FOXP3⁺	8.29	0.55	0.51	0.96	0.23	0.98
CD4⁺ TGF-β⁺	15.38	0.08	6.99	0.34	8.1	0.17
CD8⁺ TGF-β⁺	−1.60	0.78	3.13	0.51	1.07	0.78
CD4⁺ CD28⁻ CD57⁺	−0.249	0.77	−0.02	0.98	−0.01	0.98
CD8⁺ CD28⁻ CD57⁺	−0.72	0.07	−0.44	0.18	−0.41	0.12
CD4⁺ PD1⁺	5.15	0.31	5.74	0.17	3.82	0.26
CD8⁺ PD1⁺	−10.34	0.02	−6.96	0.05	−6.19	0.03
CD4⁺ CD31⁺	−15.97	0.06	−14.02	0.05	−11.74	0.04
CD8⁺ CD31⁺	6.69	0.42	7.83	0.25	5.85	0.29

Boldface type indicates statistically significant effects defined by a P value of <0.02 to adjust for multiple comparisons. Abbreviations: VZV, varicella-zoster virus; Th1, T helper 1; SFC, spot-forming cells/10⁶ PBMC; RCE, regression coefficient estimate (indicates the magnitude of the difference); baseline responses, prevaccination responses in the same category as the outcome measure (e.g., prevaccination IFN-γ SFC as an explanatory variable for peak IFN-γ SFC or prevaccination IL-2 SFC as an explanatory variable for peak IL-2 SFC, etc.).