. 2019 Jul 17;93(15):e00305-19. doi: 10.1128/JVI.00305-19

TABLE 8.

Multivariable regression analysis of the effects of age and baseline and peak immune parameters on the magnitude of persistent VZV-specific Th1 cells 1 year after ZVL administration in the flow cytometry group of the primary cohort (n = 95)^a

Explanatory variable	IL-2⁺ SFC		IFN-γ⁺ SFC		IFN-γ⁺ IL-2⁺ SFC
Explanatory variable	RCE	P	RCE	P	RCE	P
Age	−2.46	0.04	−1.45	0.14	−1.83	0.02
Baseline value	0.27	0.07	0.72	<0.001	0.39	0.01
Peak value	0.46	<0.001	0.10	0.15	0.35	<0.001
VZV CD4⁺ CD39⁺	−28.85	0.33	−47.73	0.11	−26.63	0.20
VZV CD8⁺ CD39⁺	−1.36	0.94	12.98	0.43	−2.02	0.86
VZV CD4⁺ FOXP3⁺	7.74	0.86	36.91	0.38	7.44	0.81
VZV CD8⁺ FOXP3⁺	12.18	0.59	7	0.75	10.36	0.51
VZV CD4⁺ IL-10⁺	16.61	0.73	44.86	0.35	0.41	0.99
VZV CD8⁺ IL-10⁺	−50.42	0.15	−42.25	0.23	−24.24	0.33
VZV CD4⁺ TGF-β⁺	8.93	0.68	−10.27	0.63	−0.51	0.97
VZV CD8⁺ TGF-β⁺	4.41	0.7	6.16	0.59	4.39	0.59

Boldface type indicates statistically significant effects. Abbreviations: VZV, varicella-zoster virus; Th1, T helper 1; RCE, regression coefficient estimate (indicates the magnitude of the effect of the explanatory variable on the outcome measure); SFC, spot-forming cells/10⁶ PBMC; baseline responses, prevaccination responses in the same category as the outcome measure (e.g., prevaccination IFN-γ SFC as an explanatory variable for peak IFN-γ SFC or prevaccination IL-2 SFC as an explanatory variable for peak IL-2 SFC, etc.).