Fig. 6.

Driver summary and actionable mutations. a Number of mutations (SNV, indel, CNV, SV) in mucosal melanoma driver genes (defined as SMGs and known oncogenic activating mutations or LoF mutations in tumor suppressor genes in other cancer types) identified in this study. b Mutations per sample in driver genes. c Samples that have mutations (SNVs, indels, copy number amplification or homozygous deletion or SV fusion gene) that are predicted to be responsive to inhibitors by Cancer Genome Interpreter. Each actionable mutation is colored by evidence level: case report, early trials, late trials, NCNN (National Comprehensive Cancer Network) guidelines, FDA (Food and Drug administration) guidelines. d Samples that have mutations (SNVs, indels, copy number amplification or homozygous deletion or SV fusion gene) that are predicted to be resistant or non-responsive to inhibitors by Cancer Genome Interpreter. Each actionable mutation is colored by evidence level: case report, early trials, late trials, NCNN guidelines, FDA guidelines