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. 2019 Jul 18;9:10442. doi: 10.1038/s41598-019-46540-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Example view of putative drug target gene in the signaling network. Nodes in blue, purple, red and green represent DTG, DTG as well as PDRG, PDRG and other gene nodes, respectively. Predicted positive gene nodes are with black border, and predicted negative nodes are with gray border. Edges in arrow (red), T-shaped (green) and full line (gray) represent positive, negative and physical interactions, respectively.