Fig. 6.

GPA-6 functions in ASH sensory neurons to mediate osas#9 response. a Screen of mutations in Gα subunits resulted in identification of the Gα subunit, gpa-6, which was defective in avoidance response to osas#9, n ≥ 3 trials. b Expression of gpa-6 in ASH neurons using nhr-79 promoter reconstituted avoidance response similar to wild-type animals, n ≥ 3 trials. c gpa-6 localizes to the soma and cilia in ASH neurons. Translational fusion of the entire gpa-6 genomic region displayed localization of the subunit to the soma of AWA, AWB, and ASH neurons. In addition, we also observed ciliary localization in ASH neurons (×40 magnification, scale bar denotes 10 µm). Data presented as mean ± S.E.M; *p < 0.05, **p < 0.01, ***p < 0.001. One factor ANOVA with Sidak’s multiple comparison posttest